Lai, Xingrong; Sun, Yanhua; Zhang, Xuedi; Wang, Dan; Wang, Jialing; Wang, Haihua; Zhao, Yao; Liu, Xinling; Xu, Xin; Song, Haoran; Ping, Wenjia; Sun, Yanli; Hu, Zhenbo published the artcile< Honokiol induces ferroptosis by upregulating HMOX1 in acute myeloid leukemia cells>, Reference of 347174-05-4, the main research area is acute myeloid leukemia ferroptosis Honokiol HMOX1; AML; ferroptosis; heme oxygenase (HO)-1; honokiol; lipid peroxidation.
Acute myeloid leukemia (AML) is one of the malignant hematol. cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small mol. compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol′s potential biol. pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML.
Frontiers in Pharmacology published new progress about Acute myeloid leukemia. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Reference of 347174-05-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics