Kowalczyk, Dorota; Albrecht, Lukasz published the artcile< Vinylogous Nucleophiles Bearing the Endocyclic Double Bond in the Allylic Alkylation with Morita-Baylis-Hillman Carbonates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coumarin methyl carbonate Morita Baylis Hillman chiral allylic alkylation; homoallylic coumarin stereoselective preparation.
This study demonstrates that vinylogous transfer of nucleophilicity in the allylic alkylation with Morita-Baylis-Hillman carbonates can be accomplished through the endocyclic double bond in 3-cyano-4-methylcoumarins. The developed reaction provides a straightforward access to functionalized coumarin derivativesI (EWG = CO2Me, CO2Et, CO2Bu-t, CN; R1 = Ph, 4-CF3C6H4, 4-BrC6H4, etc.; R2 = H, 6-Cl, 6-Br, etc.) of biol. and synthetic relevance. Target, highly functionalized products have been chemoselectively and efficiently obtained in very high yield (up to 98%) and with excellent enantioselectivity (up to 99.5:0.5 er).
Advanced Synthesis & Catalysis published new progress about Allylic alkylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics