French, Frederic A.; DoAmaral, Jefferson R.; Blanz, Erwin J. Jr.; French, Douglas A. published the artcile< Antimalarial activity of guanylhydrazone salts of aromatic ketones. 2. Development of active polyhalo derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antimalarial halobenzophenone guanyl hydrazones; Plasmodium benzophenones guanylhydrazones.
The requirement for the antimalarial activity of the halogen-substituent benzophenone guanylhydrazones Ph2C:NNHC(NH2:HCl) was the presence of a CF3 group in the 3 or 4 position or a F3CO group in the 4 position on one ring, and a halogen or CF3 in the 3 or 4 position of the 2nd ring. Twenty-five compounds containing halogen, CF3 or F3CO groups, substituted in various ring positions were synthesized by known methods and tested on mice infected with Plasmodium berghei. Fifteen compounds were active and 16 were partially curative. Twelve compounds produced 100% cures at one or more dose levels. 3,4-Dichloro-4′-trifluoromethylbenzophenone guanylhydrazone-HCl (I-HCl) was outstanding and yielded 100% cures with 80-640 mg/kg doses. Replacement of H by Me in the guanidine moiety abolished the antimalarial activity.
Journal of Medicinal Chemistry published new progress about Malaria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics