Feng, Chuchu; Wu, Yu; Chen, Yantao; Xiong, Xilin; Li, Peng; Peng, Xiaomin; Li, Chunmou; Weng, Wenjun; Zhu, Yafeng; Zhou, Dunhua; Li, Yang published the artcile< Arsenic trioxide increases apoptosis of SK-N-BE (2) cells partially by inducing GPX4-mediated ferroptosis>, Application In Synthesis of 347174-05-4, the main research area is arsenic trioxide anticancer agent ferroptosis neuroblastoma; Arsenic trioxide; Ferroptosis; GPX4; Neuroblastoma; Quantitative proteomic analysis.
Neuroblastoma (NB) is the most common extracranial tumor in central nervous system threatening childrens health with limited therapeutic options. Arsenic trioxide (ATO) has been identified the cytotoxicity in NB cells but the potential mechanism remains unclear. In this study, we attempted to obtain some insight into the mechanisms of cell death induced by ATO in NB cells. Proteomic analyses found that ATO can affect the signaling pathway associated with ferroptosis, including the upregulation of iron absorption (FTL, FTH1, HO-1), ferritinophagy (LC3, P62, ATG7, NCOA4) and modifier of glutathione synthesis (GCLM); downregulation of glutamine synthetase (GS) and GPX4, which was the critical inhibitor of ferroptosis. Western blot anal. revealing GPX4 expression in SK-N-BE (2) cells decreased after treatment with ATO (7.3μM), resulting in a loss of GPX4 activity. Furthermore, Ferroptosis inhibitor ferrostatin-1 partially blocked ATO-induced cell death. Our study revealed that ATO may induce ferroptosis in neuroblastoma cell SK-N-BE (2) by facilitating the downregulation of GPX4, ultimately resulting in iron-dependent oxidative death.
Molecular Biology Reports published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application In Synthesis of 347174-05-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics