Vila, Carlos; Dharmaraj, Nisshanth Raj; Faubel, Antonio; Blay, Gonzalo; Cardona, M. Luz; Munoz, M. Carmen; Pedro, Jose R. published the artcile< Regio-, Diastereo-, and Enantioselective Organocatalytic Addition of 4-Substituted Pyrazolones to Isatin-Derived Nitroalkenes>, Category: esters-buliding-blocks, the main research area is pyrazolone nitroalkene organocatalyst regioselective enantioselective diastereoselective nucleophilic vinylic substitution; chiral alkenylpyrazolone stereoselective preparation; hydroquinine diphenyl pyrimidinediyl diether catalyst.
Hydroquinine 2,5-diphenyl-4,6-pyrimidinediyl diether [(DHQ)2Pyr] catalyzed the regio-, diastereo-, and enantioselective addition of 4-substituted pyrazolones to isatin-derived nitroalkenes, providing a variety of chiral alkenylpyrazolone adducts, e.g., I, containing a tetrasubstituted stereocenter bearing an oxindole moiety with excellent yields, regioselectivity, and diastereoselectivity, as well as a moderate enantioselectivity (up to 98 % yield, > 20:1 E/Z ratio dr and 78 % ee). The reaction harnesses a nitroalkene as an alkenylating agent through a Nucleophilic Vinylic Substitution (SNV) reaction.
European Journal of Organic Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (isatin-derived). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics