Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 611-13-2, formula is C6H6O3, Name is Methyl furan-2-carboxylate. as in the substitution reaction of a carboxylic acid and an alcohol. Computed Properties of 611-13-2.
Zhang, Rui;Yao, Wei-Zhong;Qian, Liang;Sang, Wei;Yuan, Ye;Du, Min-Chen;Cheng, Hua;Chen, Cheng;Qin, Xin research published 《 A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions》, the research content is summarized as follows. In this paper, a NaOtBu-mediated synthesis approach was developed for direct amidation of unactivated esters RC(O)OR1 (R = Ph, pyridin-2-yl, cyclopropyl, Me, pyrazin-2-yl, etc.; R1 = Me, Et, Ph, etc.) with amines R2R3NH (R2 = Ph, n-hexyl, benzyl, etc.; R3 = H, Me; R2R3 = -(CH2)5-, -(CH2)2O(CH2)2-) under transition-metal-free and solvent-free conditions, affording a series of amides R(CO)NR2R3 in good to excellent yields at room temperature In particular, an environmentally friendly and practical workup procedure, which circumvents the use of organic solvents and chromatog. in most cases, was disclosed. Moreover, the gram-scale production of representative products R(CO)NR2R3 (R = Ph, R2 = Ph, 2-phenylethyl, R3 = H; R = Me, R2 = Ph, R3 = H) was efficiently realized by applying operationally simple, sustainable and practical procedures. Furthermore, this approach was also applicable to the synthesis of valuable mols. such as moclobemide (a powerful antidepressant), benodanil and fenfuram (two com. agricultural fungicides). These results demonstrate that this protocol has the potential to streamline amide synthesis in industry. Meanwhile, quant. green metrics of all the target products were evaluated, implying that the present protocol is advantageous over the reported ones in terms of environmental friendliness and sustainability. Finally, addnl. experiments and computational calculations were carried out to elucidate the mechanistic insight of this transformation, and one plausible mechanism was provided on the basis of these results and the related literature reports.
611-13-2, Methyl 2-furoate has been identified as one of the volatile flavor compounds in tequila, okra, berrycactus and black currant juice.
Methyl 2-furoate, also known as fema 2703 or methyl pyromucate, belongs to the class of organic compounds known as furoic acid esters. These are ester derivatives of furoic acid. Methyl 2-furoate is soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Within the cell, methyl 2-furoate is primarily located in the cytoplasm. Methyl 2-furoate is a sweet, fruity, and fungal tasting compound that can be found in a number of food items such as cocoa and cocoa products, potato, tamarind, and fruits. This makes methyl 2-furoate a potential biomarker for the consumption of these food products.
Methyl 2-furoate is a reactive compound that belongs to the family of sesquiterpene lactones. It has been shown to have phosphotungstic acid and hydrochloric acid reactivity, as well as nitrous and water vapor sensitivity. Methyl 2-furoate also reacts with radiation, which can be used for structural analysis. The compound is an intermediate in the synthesis of pluronic p123, which is used in fabricating biomedical devices. Methyl 2-furoate has been shown to have anti-inflammatory properties through its inhibitory effect on prostaglandin synthesis., Computed Properties of 611-13-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics