Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Product Details of C8H9BO4.
Miles, Dillon H.;Yan, Xuelei;Thomas-Tran, Rhiannon;Fournier, Jeremy;Sharif, Ehesan U.;Drew, Samuel L.;Mata, Guillaume;Lawson, Kenneth V.;Ginn, Elaine;Wong, Kent;Soni, Divyank;Dhanota, Puja;Shaqfeh, Stefan G.;Meleza, Cesar;Chen, Ada;Pham, Amber T.;Park, Timothy;Swinarski, Debbie;Banuelos, Jesus;Schindler, Ulrike;Walters, Matthew J.;Walker, Nigel P.;Zhao, Xiaoning;Young, Stephen W.;Chen, Jie;Jin, Lixia;Leleti, Manmohan Reddy;Powers, Jay P.;Jeffrey, Jenna L. research published 《 Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors》, the research content is summarized as follows. The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated with tumor immunosuppression and growth. Selective inhibition of PI3Kγ offers a promising strategy in immuno-oncol., which has led to the development of numerous potent PI3Kγ inhibitors with variable selectivity profiles. To facilitate further investigation of the therapeutic potential of PI3Kγ inhibition, we required a potent and PI3Kγ-selective tool compound with sufficient metabolic stability for use in future in vivo studies. Herein, we describe some of our efforts to realize this goal through the systematic study of SARs within a series of 7-azaindole-based PI3Kγ inhibitors. The large volume of data generated from this study helped guide our subsequent lead optimization efforts and will inform further development of PI3Kγ-selective inhibitors for use in immunomodulation.
99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Product Details of C8H9BO4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics