Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52727-57-8, name is Methyl 2-amino-5-bromobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8BrNO2
A suspension of methyl 2-amino-5-bromobenzoate (460 mg, 2.0 mmol), potassium acetate (441 mg, 4.5 mmol) and pinacol diborane (1.52 g, 6.0 mmol) in 1,4-dioxane (20 mL) was degassed under a flow of N2 for 15 minutes. PdCb(dppf) (73 mg, 0.1 mmol) was added and the mixture heated to 95C for 16 hours. The reaction was deemed complete by LCMS. After cooling, the contents were partitioned between CH2C12 and water. The organic layer was washed with water, dried over anhydrous MgS04, filtered and evaporated. The product was purified by automated silica-gel chromatography eluting with a hexanes/EtOAc gradient. The fractions containing methyl 2- amino-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzoate were concentrated to yield the product as a colorless oil = 560 mg (2.00 mmol, quant.). (0566) LC/MS – HPLC (254 nm) – Rt 3.32 min. MS (ESI) m/z 278.3 [M + H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SIGNALRX PHARMACEUTICALS, INC.; MORALES, Guilermo, A.; GARLICH, Joseph, R.; DURDEN, Donald, L.; (166 pag.)WO2018/140730; (2018); A1;,
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