Kim, Mahn Joo; Whitesides, George M. published the artcile< L-Lactate dehydrogenase: substrate specificity and use as a catalyst in the synthesis of homochiral 2-hydroxy acids>, Application In Synthesis of 112-63-0, the main research area is oxo carboxylate reduction lactate dehydrogenase; hydroxy acid preparation lactate dehydrogenase; butene oxide enzymic preparation.
Kinetic parameters (Km, kcat) are reported for reduction of é?0 æµ?keto acids by L-lactate dehydrogenase (L-LDH; EC 1.1.1.27) from 5 sources (porcine heart, rabbit muscle, chicken liver, bovine heart, lobster tail). The L-LDH-catalyzed reduction reaction of 4 substrates representative of the range of activities observed was done on a preparative scale by using rabbit muscle L-LDH, and absolute configurations and values of enantiomeric excess (ee) of the products were determined: 2-hydroxybutanoic acid, ee > 99% S; 2-hydroxypentanoic acid, ee >99% S; cyclopropaneglycolic acid, ee >99% S; 3-phenyllactic acid, ee >99% S. This enzyme-catalyzed reduction provides a practical method for preparing 1-25-g quantities of a range of 2-hydroxy acids with high ee. To illustrate the value of these compounds as chiral synthons, (S)-2-hydroxybutanoic acid was converted to (S)-1-butene oxide having >98% ee on a 6-g scale.
Journal of the American Chemical Society published new progress about Chiral synthons. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics