On August 2, 2021, Li, Fuzhuo; Yang, Li-Cheng; Zhang, Jingyang; Chen, Jason S.; Renata, Hans published an article.Quality Control of (R)-Methyl 3-hydroxybutanoate The title of the article was Stereoselective synthesis of β-branched aromatic α-amino acids by biocatalytic dynamic kinetic resolution. And the article contained the following:
β-Branched noncanonical amino acids are valuable mols. in modern drug development efforts. However, they are still challenging to prepare due to the need to set multiple stereocenters in a stereoselective fashion, and contemporary methods for the synthesis of such compounds often rely on the use of rare-transition-metal catalysts with designer ligands. Herein, we report a highly diastereo- and enantioselective biocatalytic transamination method to prepare a broad range of aromatic β-branched α-amino acids. Mechanistic studies show that the transformation proceeds through dynamic kinetic resolution that is unique to the optimal enzyme. To highlight its utility and practicality, the biocatalytic reaction was applied to the synthesis of several sp3-rich cyclic fragments and the first total synthesis of jomthonic acid A. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Quality Control of (R)-Methyl 3-hydroxybutanoate
The Article related to branched aromatic amino acid diastereoselective enantioselective biocatalytic synthesis, ketoacid transamination amino acid catalyst dynamic kinetic resolution enzymic, stereoselective enzymic dynamic kinetic resolution reaction mechanism chirality, asymmetric synthesis, biocatalysis, dynamic kinetic resolution, noncanonical amino acids, transaminases and other aspects.Quality Control of (R)-Methyl 3-hydroxybutanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics