Song, Bo; Zhang, Xinyue; Wen, Xinyi; Liu, Qi; Ma, Hua; Guo, Weihua; Tan, Mingqian; Jia, Lei; Yuan, Jingli published an article in 2021. The article was titled 《Development of a tumor-targetable heteropolymetallic lanthanide-complex-based magnetoluminescent probe for dual-modal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo》, and you may find the article in New Journal of Chemistry.Product Details of 51857-17-1 The information in the text is summarized as follows:
Probes combining luminescence and magnetic resonance (MR) imaging activities have attracted tremendous attention since they can offer both mol. and anatomical information to effectively improve the accuracy of detection. In this work, a β-diketone ligand (CDHH) was modified by covalent conjugation with an MRI contrast agent (DO3A-Gd) and a tumor-targetable biomacromol. transferrin (Tf). When Eu3+ ions were added into the mixture of two functionalized β-diketone ligands, they triggered a self-assembly to form a heteropolymetallic lanthanide complex that was conjugated to Tf. The as-prepared bioconjugate, i.e., Tf-Eu-Gd, exhibited intense long-lived luminescence (ϕ = 0.20, τ = 0.34 ms), remarkably high MR relaxivities (r1 = 9.18 mM-1 s-1 and r2 = 12.03 mM-1 s-1), as well as good water solubility, stability, and biocompatibility. Time-gated luminescence (TGL) imaging of live cells using Tf-Eu-Gd as a probe demonstrated that the probe can distinguish Tf-receptor-overexpressed cancerous cells, which enables the probe to be specifically accumulated in these cells. On the basis of magnetoluminescent properties of Tf-Eu-Gd, it was further used as a bimodal probe for both TGL and MR imaging of cancerous cells in tumor-bearing nude mice. The results indicated that Tf-Eu-Gd could significantly increase the T1-weighted MRI contrast value in the tumor region, and the TGL imaging of tumor tissue sections provided clear histol. validation of the MRI signals. The research outcomes revealed the feasibility of Tf-Eu-Gd for the tracing and precise detection of cancerous cells, which suggested its potential for serving to the clin. diagnosis, therapy, and medical research of tumor diseases. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Product Details of 51857-17-1
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