In 2015,Neubert, Timothy D.; Schmidt, Yvonne; Conroy, Erica; Stamos, Dean published 《Radical Mediated C-H Functionalization of 3,6-Dichloropyridazine: Efficient Access to Novel Tetrahydropyridopyridazines》.Organic Letters published the findings.Category: esters-buliding-blocks The information in the text is summarized as follows:
A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcs., t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines, e.g., I (X-rays single crystal structure shown), with multiple functional handles. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Category: esters-buliding-blocks)
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics