These common heterocyclic compound, 14273-90-6, name is Methyl 6-bromohexanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 6-bromohexanoate
Step-II: Preparation of methyl 6-(3-(benzo[d]oxazol-2-yl)-4-oxoquinolin-l(4H)- yl)hexanoate; To a mixture of 3-(benzo[d]oxazol-2-yl)quinolin-4(lH)-one (0.05 g, 1.9 mmol) and anhydrous K2CO3 (0.078 g, 5.7 mmol) in DMF (5 mL), methyl 6-bromohexanoate(0.079g, 3.8 mmol) was added and heated under microwave at 125 0C for 20 minutes. The reaction mixture was poured into ice-cold water (10 mL) and extracted with ethyl acetate (25 mL). The organic layer was washed with water, brine solution each 10 mL.The organic layer was dried over Na2SO4 and concentrated to afford the crude compound, was purified by column chromatography using 20percent ethyl acetate in hexane as an eluent. The pure fraction was concentrated to afford the title compound as colourless solid (0.055 g, 74.32 percent yield).
The synthetic route of Methyl 6-bromohexanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORCHID RESEARCH LABORATORIES LTD.; BALASUBRAMANIAN, Gopalan; RAJAGOPAL, Sridharan; RATHINASAMY, Suresh; KILAMBI, Narasimhan; RAJENDRAN, Praveen; NARAYANAN, Shridhar; WO2010/73078; (2010); A2;,
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