In 2022,Rita Neves, Ana; Vilas Boas, Catia; Goncalves, Catarina; Vasconcelos, Vitor; Pinto, Madalena; Silva, Elisabete R.; Sousa, Emilia; Almeida, Joana R.; Correia-da-Silva, Marta published an article in Bioorganic Chemistry. The title of the article was 《Gallic acid derivatives as inhibitors of mussel (Mytilus galloprovincialis) larval settlement: Lead optimization, biological evaluation and use in antifouling coatings》.Safety of N-Boc-1,6-Diaminohexane The author mentioned the following in the article:
The addition of biocides to marine coatings has been the most used solution to avoid marine biofouling, however they are persistent, bioaccumulative, and toxic (PBT) to marine ecosystems. The development of natural products or Nature-inspired synthetic compounds to replace these harmfull biocides has been pursued as one of the most promising antifouling (AF) alternatives. Following a bioprospection strategy, we have previously reported the AF activity of gallic acid persulfate (1) against the settlement of Mytilus galloprovincialis larvae (EC50 = 18 μM and LC50/EC50 = 27) without exhibiting ecotoxicity to Artemia salina. In this work, a lead optimization strategy was applied to compound gallic acid persulfate in order to improve potency while maintaining a low ecotoxicity profile. In this direction, twenty-seven compounds were synthesized, from which eighteen were obtained for the first time. An AF screening was performed against the settlement of mussel M. galloprovincialis larvae and 2-(3,4,5-trihydroxybenzamido)ethan-1-aminium bromide, was found to be more potent (EC50 = 3 μM and LC50/EC50 = 73) than compound 1 and the biocide Econea (EC50 = 4 μM). The potential impact on neurotransmission, and ecotoxicity against two non-target marine organisms was also evaluated. Marine polyurethane (PU)-based coatings containing compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide were prepared and lower adherence of mussel larvae was observed compared to compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide free PU-coatings. Studies concerning the leaching of compound 2-(3,4,5-Trihydroxybenzamido)ethan-1-aminium bromide from the prepared coating were also conducted, and < 10% of this compound was detected after 45 days of submersion in water. Overall, we have optimized the potency against the settlement of mussels of our initial lead compound, not compromising the toxicity and compatibility with PU-based coatings. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane
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