D’yakonov, Vladimir A.; Tuktarova, Regina A.; Dzhemileva, Lilya U.; Ishmukhametova, Svetlana R.; Dzhemilev, Usein M. published an article in 2021. The article was titled 《Synthesis and anticancer activity of hybrid molecules based on lithocholic and (5Z,9Z)-tetradeca-5,9-dienedioic acids linked via mono(di,tri,tetra)ethylene glycol and α,ω-diaminoalkane units》, and you may find the article in Pharmaceuticals.Safety of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:
For first time, hybrid mols. were synthesized on basis of lithocholic and (5Z,9Z)-1,14-tetradeca-5,9-dienedicarboxylic acids, obtained in two stages using homo-cyclomagnesiation reaction of 2-(hepta-5,6-diene-1-yloxy)tetrahydro-2H-pyran at key stage. The resulting hybrid mols. containing 5Z,9Z-dienoic acids were of interest as novel synthetic biol. active precursors to create modern drugs for treatment of human oncol. diseases. The synthesized hybrid mols. were found to exhibit extremely high in vitro inhibitory activity against human topoisomerase I, which is 2-4 times higher than that of camptothecin, a known topoisomerase I inhibitor. Using flow cytometry and fluorescence microscopy, it was first shown that these new mols. are efficient apoptosis inducers in HeLa, U937, Jurkat, K562, and Hek293 cell cultures. In addition, results of investigations into effect of synthesized acids on mitochondria and studies of possible DNA damage in Jurkat tumor cells are also presented. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane) was used in this study.
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsSafety of N-Boc-1,6-Diaminohexane
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