Synthetic Route of 18927-05-4,Some common heterocyclic compound, 18927-05-4, name is Methyl 3-Methoxyphenylacetate, molecular formula is C10H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Nitrobenzene (0.4 mmol), methylmethoxyphenylacetate (0.2 mmol),Dimethyl sulfoxide (0.5 mL) and sodium tert-butoxide (0.4 mmol) were successively added to the reaction flask and the reaction was carried out at 45 C for 8 hours. The reaction product was separated from the reaction solution by adding water, dilute hydrochloric acid and ethyl acetate, and the product was isolated by silica gel column chromatography. The yield was 43%, yellow solid,
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-Methoxyphenylacetate, its application will become more common.
Reference:
Patent; Changsha University of Science and Technology; Li Jiangsheng; Yang Fan; Yang Qian; Li Zhiwei; Chen Guoqin; (8 pag.)CN107033006; (2017); A;,
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