Shariff, Azim; McLean, Stewart published the artcile< The synthesis of Nauclea indole-pyridine alkaloids. 3,4-Disubstituted and 3,4,5-trisubstituted pyridines as synthetic intermediates; a total synthesis of (±)-decarbomethoxy-3α- and -3β-nauclechine>, Quality Control of 33402-75-4, the main research area is nauclechine decarbomethoxy epimer synthesis; pyridine substituted; pyridineacetic acid substituted Bischler Napieralski; Nauclea indole pyridine alkaloid.
Synthetic routes to a number of 3,4-disubstituted and 3,4,5-trisubstituted pyridines was explored. These pyridines, designed to be used in the synthesis of Nauclea indole-pyridine alkaloids, are potentially useful intermediates in a number of syntheses. Substituted 4-pyridineacetic acids were prepared and the exptl. limitations associated with their synthesis and use in subsequent reactions such as the Bischler-Napieralski cyclization were discussed. A synthesis of decarbomethoxynauclechine from 4-methylnicotinaldehyde avoiding these difficulties was described. (±)-Decarbomethoxy-3α-nauclechine (I; R = α-H) and (±)-decarbomethoxy-3β-nauclechine (I; R = β-H) were obtained and their structure and stereochem. were established, but it was not possible to demonstrate which corresponded to the natural alkaloid, decarbomethoxynauclechine.
Canadian Journal of Chemistry published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Quality Control of 33402-75-4.
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