Landagaray, Elodie; Ettaoussi, Mohamed; Rami, Marouan; Boutin, Jean A.; Caignard, Daniel-Henri; Delagrange, Philippe; Melnyk, Patricia; Berthelot, Pascal; Yous, Said published the artcile< New quinolinic derivatives as melatonergic ligands: Synthesis and pharmacological evaluation>, Application In Synthesis of 112-63-0, the main research area is quinolinic derivative preparation pharmacol evaluation SAR melatonergic ligand; Agonist; MT(1); MT(2)-Selectivity; Melatonin; Quinoline derivatives.
New series of melatonergic ligands issued from two methoxy-quinolinic scaffolds (2-MQ and 3-MQ), were designed and synthesized. Herein we report the synthetic scheme and pharmacol. results of the new prepared compounds Investigation of compound I (X = O, R = Me), the strict 2-MQ analog, revealed the promising potential of this series. Therefore, pharmacomodulation of the acetamide function of I (X = O, R = Me) has led to compounds with different pharmacol. profiles and the emergence of an MT2 selectivity. Besides, sulfonamide II showed the most important MT2 selectivity of this series (167 folds) while Me and ethyl-ureas I (X = O, R = NHMe, NHEt) represented the most potent melatonergic ligands of this study.
European Journal of Medicinal Chemistry published new progress about Melatonin receptor 1A Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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