Gao, Zhen xing; Cui, Ze long; Zhou, Min ran; Fu, Yue; Liu, Fen; Zhang, Lu; Ma, Sai; Chen, Chun yan published the artcile< The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia>, Related Products of 347174-05-4, the main research area is BAM15 anticancer agent reactive oxygen species acute myeloid leukemia; Apoptosis; BAM15; Leukemia; Primary cells; Proliferation; ROS.
Acute myeloid leukemia (AML) is a malignant proliferative disease of myeloid hematopoietic origin and cannot be treated appropriately at present. This is due to the fact that leukemia cells are not sensitive to some of the traditional chemotherapy drugs. Or some chemotherapeutic drugs are too toxic to normal cells, affecting their wide clin. application. In this study, we identified BAM15 as a novel mitochondrial uncoupling agent by screening a library of small mol. compounds that inhibit AML cell activity. BAM15 significantly inhibited proliferation and promoted apoptosis in AML cells while at the same time being less cytotoxic to normal cells. The mechanism may be related to the disturbance of the ROS production balance. In vivo investigations revealed that BAM15 effectively suppressed AML progression and prolonged the survival time of mice. In addition, we found that BAM15 can be used in combination with cytarabine to enhance its anti-cancer activity and inhibit the activity of primary cells in AML. Therefore, we identified BAM15 as a potential drug candidate for the treatment of AML.
Biochemical Pharmacology (Amsterdam, Netherlands) published new progress about Acute myeloid leukemia. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Related Products of 347174-05-4.
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