Related Products of 30414-53-0On March 1, 2019, Huang, Wenbo; Xu, Jing; Liu, Changhui; Chen, Zhiyan; Gu, Yanlong published an article in Journal of Organic Chemistry. The article was 《Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds》. The article mentions the following:
2,3-Disubstituted benzofurans such as benzofurandicarboxylate I were prepared by cyclocondensation of acrolein dimer (2H-3,4-dihydro-2-pyrancarboxaldehyde) and 1,3-dicarbonyl compounds, particularly β-ketoesters and 1,3-diketones, in the presence of Lewis acid catalysts [either AlCl3 or Sc(OTf)3 or in one case, BF3·Et2O] using N-bromosuccinimide (NBS) as an oxidant. The method was used to prepare benzbromarone and amiodarone. An oxobutylfurancarboxylate intermediate in the cyclocondensation of acrolein dimer and Me acetoacetate was isolated; cyclocondensation with indoles, 1,2,4-trimethoxybenzene, and 1,1-diphenylethylene yielded aryl- and diphenylvinyl-substituted tetrahydrobenzofurancarboxylates such as II [R = 3-indolyl, 1-methyl-3-indolyl, 2,4,5-(MeO)3C6H2, Ph2C:CH]. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0Related Products of 30414-53-0)
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Related Products of 30414-53-0
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