The author of 《A three-component approach to isoxazolines and isoxazoles under metal-free conditions》 were Wang, Dahan; Zhang, Feng; Xiao, Fuhong; Deng, Guo-Jun. And the article was published in Organic & Biomolecular Chemistry in 2019. Application In Synthesis of Ethyl propiolate The author mentioned the following in the article:
A 1,3-dipolar cycloaddition of 2-methylquinolines I (R = H, 6-F, 8-OMe, 7-Cl, etc.), tert-Bu nitrite (TBN) and alkynes R1CCR2 (R1 = H, C(O)2Me, C(O)2Et; R2 = 4-methylphenyl, C(O)2Me, 2-hydroxyethyl, pyridin-2-yl, etc.) or alkenes R3CH=CH2 (R3 = Ph, benzyl, chloromethyl, etc.) for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs II (R4 = quinolin-2-yl) and IIIhas been developed. In this protocol, TBN serves as a convenient N-O source to convert 2-methylquinoline into intermediate nitrile oxides in situ. In the experimental materials used by the author, we found Ethyl propiolate(cas: 623-47-2Application In Synthesis of Ethyl propiolate)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Application In Synthesis of Ethyl propiolate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics