In 2003,Lahue, Brian R.; Wan, Zhao-Kui; Snyder, John K. published 《Dienophilicity of Imidazole in Inverse Electron Demand Diels-Alder Reactions. 4. Intermolecular Reactions with 1,2,4-Triazines》.Journal of Organic Chemistry published the findings.SDS of cas: 16982-21-1 The information in the text is summarized as follows:
Intermol. inverse electron demand cycloadditions of 2-substituted imidazoles I (R1 = Me2N, MeS, Me2NCH:N, Me2NCMe:N) with various 1,2,4-triazines II (R2 = R3 = Ph, MeO2C, EtO2C; R2 = H, R3 = Ph, EtO2C) produced both imidazo[4,5-c]pyridines (3-deazapurines) III and pyrido[3,2-d]pyrimidin-4-ones (8-deazapteridines) IV. The product distribution was controlled by reactant substituents and influenced by reaction temperature A regioselective method for the preparation of 6-unsubstituted 1,2,4-triazines II (R2 = H) was also developed. By using this route to 8-deazapteridines, a new 8-deazafolate analog was prepared After reading the article, we found that the author used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1SDS of cas: 16982-21-1)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.SDS of cas: 16982-21-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics