《An improved synthesis of hemichrysophaentin-AB fragment of chrysophaentin A》 was published in Tetrahedron Letters in 2020. These research results belong to Fullenkamp, Christopher R.; Sulikowski, Gary A.. Category: esters-buliding-blocks The article mentions the following:
Synthetic fragments of chrysophaentin A, a rare antimicrobial marine natural product, were required to support structure-activity and mechanism of action studies. Hemichrysophaentin (I), a synthetic fragment of chrysophaentin A showed antimicrobial activity against Gram-pos. bacteria, presumably acting through the inhibition of the microbial tubulin-like protein FtsZ. Here in, we report a concise and scalable 11-step synthesis of hemichrysophaentin featuring a stereo- and regiocontrolled installation of an E-chloroalkene followed by a Lewis acid promoted O to C migration.Ethyl propiolate(cas: 623-47-2Category: esters-buliding-blocks) was used in this study.
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics