Joshi, Dirgha Raj; Kim, Ikyon published their research in Journal of Organic Chemistry in 2021. The article was titled 《Michael-Aldol Double Elimination Cascade to Make Pyridines: Use of Chromone for the Synthesis of Indolizines》.Quality Control of Ethyl propiolate The article contains the following contents:
A domino Michael-aldol double elimination route to indolizines having two different acyl groups at the C5 and C7 positions was described where chromone was employed as a two-carbon unit for the synthesis of a pyridine moiety for the first time. Various analogs were readily accessed in good yields under metal-free and eco-friendly conditions. Further manipulation of the resulting products allowed entry to novel indolizine-heterocycle adducts, which were difficult to access by other methods. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2Quality Control of Ethyl propiolate)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Quality Control of Ethyl propiolate
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