In 2009,Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P. published 《Searching for New Cures for Tuberculosis: Design, Synthesis, and Biological Evaluation of 2-Methylbenzothiazoles》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 16982-21-1 The information in the text is summarized as follows:
The actual development and clin. use of new therapeutics for tuberculosis have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6 mo period. In this study, the chem. and biol. of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamides, e.g. I [R = Me2N, 1-piperidinyl, (S)-MeO2CCH(Ph)NH, etc.] , which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H37Rv, are reported. The most potent compounds I [R = (S)- or (R)-MeO2CCH(Ph)NH] were found to inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.9 μM, resp. Impressively, all active compounds were nontoxic toward Vero cells (IC50 > 128 μM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as antitubercular drugs and as possible antimalaria drugs.Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1HPLC of Formula: 16982-21-1) was used in this study.
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).HPLC of Formula: 16982-21-1
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