COA of Formula: C10H22N2O2In 2021 ,《Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design》 was published in Bioorganic & Medicinal Chemistry. The article was written by Xiao, Ganyuan; Alphey, Magnus S.; Tran, Fanny; Pirrie, Lisa; Milbeo, Pierre; Zhou, Yi; Bickel, Jasmine K.; Kempf, Oxana; Kempf, Karl; Naismith, James H.; Westwood, Nicholas J.. The article contains the following contents:
The monosaccharide L-Rhamnose is an important component of bacterial cell walls. The first step in the L-rhamnose biosynthetic pathway is catalyzed by glucose-1-phosphate thymidylyltransferase (RmlA), which condenses glucose-1-phosphate (Glu-1-P) with deoxythymidine triphosphate (dTTP) to yield dTDP-D-glucose. In addition to the active site where catalysis of this reaction occurs, RmlA has an allosteric site that is important for its function. Building on previous reports, SAR studies have explored further the allosteric site, leading to the identification of very potent P. aeruginosa RmlA inhibitors. Modification at the C6-NH2 of the inhibitor′s pyrimidinedione core structure was tolerated. X-ray crystallog. anal. of the complexes of P. aeruginosa RmlA with the novel analogs revealed that C6-aminoalkyl substituents can be used to position a modifiable amine just outside the allosteric pocket. This opens up the possibility of linking a siderophore to this class of inhibitor with the goal of enhancing bacterial cell wall permeability. In the experiment, the researchers used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3COA of Formula: C10H22N2O2)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).COA of Formula: C10H22N2O2
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