Quality Control of H-Trp-OMe.HClIn 2021 ,《Chemoselective peptide backbone diversification and bioorthogonal ligation by ruthenium-catalyzed C-H activation/annulation》 was published in Advanced Synthesis & Catalysis. The article was written by Song, Liangliang; Ojeda-Carralero, Gerardo M.; Parmar, Divyaakshar; Gonzalez-Martinez, David A.; Van Meervelt, Luc; Van der Eycken, Johan; Goeman, Jan; Rivera, Daniel G.; Van der Eycken, Erik V.. The article contains the following contents:
The field of peptide derivatization by metal-catalyzed C-H activation has been mostly directed to modify the side chains, but poor attention has been given to the peptide backbone. Here we report a ruthenium-catalyzed C-H activation/annulation process that can chemoselectively modify the peptide backbone producing functionalized isoquinolone scaffolds with high regioselectivity in a rapid and step-economical manner. This strategy is characterized by racemization-free conditions and the production of fluorescent peptides, and peptide conjugates to drugs, natural products and other peptide fragments, providing a chem. approach for the construction of novel peptide-pharmacophore conjugates. Mechanistic studies suggest that amide bonds of peptide backbone act as the bidentate directing group to promote the C-H activation/annulation process. This report provides an unprecedented example of peptide backbone diversification and bioorthogonal ligation exploiting the power of ruthenium-catalyzed C-H activation. The results came from multiple reactions, including the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Quality Control of H-Trp-OMe.HCl)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Quality Control of H-Trp-OMe.HCl
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