In 2011,Newton, Gerald L.; Buchmeier, Nancy; La Clair, James J.; Fahey, Robert C. published 《Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis》.Bioorganic & Medicinal Chemistry published the findings.Recommanded Product: 329-59-9 The information in the text is summarized as follows:
The mycothiol biosynthesis enzyme MshC catalyzes the ligation of cysteine with the pseudodisaccharide GlcN-Ins and has been identified as an essential enzyme in Mycobacterium tuberculosis. The authors now report on the development of NTF1836 as a micromolar inhibitor of MshC. Using com. libraries, they conducted preliminary structure-activity relationship (SAR) studies on NTF1836. NTF1836 and five structurally related compounds showed similar activity towards clin. strains of M. tuberculosis. A gram scale synthesis was developed to provide ample material for biol. studies. Using this material, the authors determined that inhibition of M. tuberculosis growth by NTF1836 was accompanied by a fall in mycothiol and an increase in GlcN-Ins consistent with the targeting of MshC. They also determined that NTF1836 kills non-replicating M. tuberculosis in the carbon starvation model of latency. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: 329-59-9)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: 329-59-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics