In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 618-89-3 as follows. Formula: C8H7BrO2
To a soiuiion of Compound 5-1 (2,00 g, 9.30 mmol, 1.00 eq) and morpholine (972 mg, 1 1.2 mmol, 1.20 eq) in toluene (20 n L) was added Cs2Ci (6.10 g, 1 8.6 mmol 2.00 eq), BINAP (289 mg, 465 umol, 0,05 eq) and Pd(OAe)2 (104 mg, 465 umo, 0.05 eq). The mixture stirred at 100 C in N2 atmosphere for 1 8 hr. The solid was filtered off and the filtrate was concentrated in vacuum. The residue was purified by column chromatography (PE:EtOAc=10: 1 to 5: 1 ) to afford Compound 6-2 (1.40 g, 69% yield) as a colorless oil. ‘HNMR: (400 MHz, CDCb) delta 7.607 (s, 3H), 7.567 (d, J=8 Hz, IH), 7.357 ( =4 Hz, I H), 7.134-7.128 (m, 4H), 3.930 (s, 3H), 3.897 (t, J-4.8 Hz, 4H), 3.230 (t, J=4.8 Hz, 4H).
According to the analysis of related databases, 618-89-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UNIVERSITY OF UTAH RESEARCH FOUNDATION; VANKAYALAPATI, Hariprasad; SHARMA, Sunil; LIU, Xiaohui; COBURN, Craig; (106 pag.)WO2017/4519; (2017); A1;,
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