Kisszekelyi, Peter; Alammar, Abdulaziz; Kupai, Jozsef; Huszthy, Peter; Barabas, Julia; Holtzl, Tibor; Szente, Lajos; Bawn, Carlo; Adams, Ralph; Szekely, Gyorgy published the artcile< Asymmetric synthesis with cinchona-decorated cyclodextrin in a continuous-flow membrane reactor>, Category: esters-buliding-blocks, the main research area is cinchona cyclodextrin organocatalyst synthesis asym Michael diketone nitrostyrene; synthesis separation integrated flow reactor cinchona cyclodextrin Michael organocatalyst.
This work presents a cyclodextrin-enhanced organocatalytic method from mol. to process design. Cinchona-thiourea and -squaramide catalysts were covalently anchored to inherently large, stable and well-defined permethyl-β-cyclodextrins. The asym. catalysis was successfully demonstrated on the Michael reaction of 1,3-diketones and trans-β-nitrostyrene. Both emerging green and conventional solvents were screened for the asym. addition (up to 99% ee), and the Kamlet-Taft solvent parameters were correlated to the enantioselectivity. Quantum chem. modeling revealed that the catalyst anchoring resulted in favorable structural changes, and stronger intermol. interactions between the catalyst and the reagents. Continuous organocatalysis was performed in coiled tube flow reactor coupled with a membrane separation unit, which allowed complete recovery of the catalyst and 50% solvent (2-MeTHF) recycling. The 100% conversion, 98% purity, 99% ee, 100% in-line catalyst recovery, and 80 g L-1 h-1 productivity makes it an attractive catalytic platform.
Journal of Catalysis published new progress about Addition reaction, stereoselective (catalysts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics