Rombouts, Frederik J. R.; Tresadern, Gary; Buijnsters, Peter; Langlois, Xavier; Tovar, Fulgencio; Steinbrecher, Thomas B.; Vanhoof, Greet; Somers, Marijke; Andres, Jose-Ignacio; Trabanco, Andres A. published the artcile< Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors>, Computed Properties of 33402-75-4, the main research area is pyrido triazolo pyrazine brain phosphodiesterase inhibitor; PDE2 inhibitor; Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazine; phosphodiesterase 2 inhibitor; selective; tricycle.
A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the Ph ring pending from the triazole. The SAR and protein flexibility were explored with free energy perturbation calculations Rat pharmacokinetic data and in vivo receptor occupancy data are given for two representative compounds 6 and 12.
ACS Medicinal Chemistry Letters published new progress about Drug bioavailability. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, Computed Properties of 33402-75-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics