Urbanczyk, Malgorzata; Jewginski, Michal; Krzciuk-Gula, Joanna; Gora, Jerzy; Latajka, Rafal; Sewald, Norbert published the artcile< Synthesis and conformational preferences of short analogs of antifreeze glycopeptides (AFGP)>, Electric Literature of 4098-06-0, the main research area is antifreeze glycopeptide analog synthesis conformation hydrogen bond cluster NMR; threonine glycosylation azido galactosyl chloride reduction; solid phase peptide synthesis acetylation antifreeze activity; NMR; PP II; antifreeze glycopeptides; conformational preferences; solid phase synthesis.
Antifreeze glycoproteins are a class of biol. agents which enable living at temperatures below the f.p. of the body fluids. Antifreeze glycopeptides usually consist of repeating tripeptide unit (-Ala-Ala-Thr*-), glycosylated at the threonine side chain. However, on the microscopic level, the mechanism of action of these compounds remains unclear. As previous research has shown, antifreeze activity of antifreeze glycopeptides strongly relies on the overall conformation of the mol. as well an on the stereochem. of amino acid residues. The desired monoglycosylated analogs with acetylated amino termini and the carboxy termini in form of N-methylamide have been synthesized. Conformational NMR (NMR) studies of the designed analogs have shown a strong influence of the stereochem. of amino acid residues on the peptide chain stability, which could be connected to the antifreeze activity of these compounds A better understanding of the mechanism of action of antifreeze glycopeptides would allow applying these materials, e.g., in food industry and biomedicine.
Beilstein Journal of Organic Chemistry published new progress about Acetylation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Electric Literature of 4098-06-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics