In 2017,Goldstein, Steven W.; Bill, Ashley; Dhuguru, Jyothi; Ghoneim, Ola published 《Nucleophilic Aromatic Substitution-Addition and Identification of an Amine》.Journal of Chemical Education published the findings.Electric Literature of C8H6FNO4 The information in the text is summarized as follows:
The addition of a nucleophilic functional group to an electron-deficient aromatic ring is a versatile reaction in the modern organic chem. arsenal. The proper positioning of a leaving group on this ring effectively allows for a substitution reaction to occur. A 3 h laboratory experiment is described in which students utilize a common electrophilic aromatic ring and affect a substitution with an unknown amine, the identity of which is later characterized by the m.p. and 1H NMR spectrum of the product. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Electric Literature of C8H6FNO4)
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Electric Literature of C8H6FNO4Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics