Recommanded Product: tert-Butyl (5-aminopentyl)carbamateIn 2016 ,《Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains》 was published in Journal of Medicinal Chemistry. The article was written by Stuckey, Jacob I.; Simpson, Catherine; Norris-Drouin, Jacqueline L.; Cholensky, Stephanie H.; Lee, Junghyun; Pasca, Ryan; Cheng, Nancy; Dickson, Bradley M.; Pearce, Kenneth H.; Frye, Stephen V.; James, Lindsey I.. The article contains the following contents:
To better understand the contribution of methyl-lysine (Kme) binding proteins to various disease states, the authors recently developed and reported the discovery of I (UNC3866), a chem. probe that targets two families of Kme binding proteins, CBX and CDY chromodomains, with selectivity for CBX4 and -7. The discovery of I was enabled in part by the use of mol. dynamics simulations performed with CBX7 and its endogenous substrate. Herein, the authors describe the design, synthesis and structure-activity relationship studies that led to the development of I and provide support for the model of CBX7-ligand recognition by examining the binding kinetics of the antagonists with CBX7 as determined by surface-plasmon resonance. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: tert-Butyl (5-aminopentyl)carbamate
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