Category: esters-buliding-blocksIn 2018 ,《Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A》 was published in ACS Medicinal Chemistry Letters. The article was written by Ahonen, Tiina J.; Savinainen, Juha R.; Yli-Kauhaluoma, Jari; Kalso, Eija; Laitinen, Jarmo T.; Moreira, Vania M.. The article contains the following contents:
Screening of an inhouse library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiazole derivative I, with an IC50 value of 3.4±0.2 μM and promising selectivity. ABHD16A has been highlighted as a new target for inflammation-mediated pain, although selective inhibitors of hABHD16A (human ABHD16A) have not yet been reported. The study presents abietane-type diterpenoids as an attractive starting point for the design of selective ABHD16A inhibitors, which will contribute toward understanding the significance of hABHD16A inhibition in vivo. In the experiment, the researchers used many compounds, for example, Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Category: esters-buliding-blocks)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: esters-buliding-blocks
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