Synthetic Route of 136333-97-6, The chemical industry reduces the impact on the environment during synthesis 136333-97-6, name is Methyl 4-(2-bromoethyl)benzoate, I believe this compound will play a more active role in future production and life.
[8911 Step 1: Synthesis of methyl4-(2-((3R.55?)-4-benzvl-3 .5-dimethvlpiperazin- 1 -vflethvl?)benzoate [8921 (2S,6R)-1-benzyl-2,6-dimethylpiperazine (formula 8-3, 0.200 g, 0.83 1 mmol) and DIPEA (0.363 mL, 2.077 mmol) were dissolved in acetonitrile (5 mL), and methyl 4-(2-bromoethyl)benzoate (formula 8-4, 0.404 g, 1.66 1 mmol) was added thereto at room temperature. The mixture was stirred at 60 C for 17 hours, and then water was added to the reaction mixture, followed by extraction with methylene chloride. The extract was passed through a plastic filter to remove solid residue and an aqueous layer, and the organic layer was concentrated under reduced pressure. The concentrate was concentrated by column chromatography (silicon dioxide; ethyl acetate/hexane = 25 %) and concentrated to afford the desired compound (0.075 g, 24.6 %) as a pale yellow oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-(2-bromoethyl)benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
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