Gok, Dervis published the artcile< One-pot three-component synthesis of novel 2-(3-nitro-phenyl)-quinazoline-4-carboxylic acid derivatives>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is quinazoline carboxylic acid preparation; nitro phenyl quinazoline carboxylic acid preparation; sodium isatinate nitrobenzaldehyde ammonium acetate three component.
A simple and easy synthesis of compound I [R1 = HO; R2 = 3-O2NC6H4] was successfully developed through a one-pot three-component condensation reaction of (2-amino-phenyl)-oxo-acetic acid sodium salt obtained from the hydrolysis of isatin with ammonium acetate and 3-nitrobenzaldehyde. Some novel quinazoline-ester derivatives I [R1 = MeO, EtO, i-PrO, BuO; R2 = 3-O2NC6H4] were then obtained by the reaction between the new compound I [R1 = H; R2 = 3-O2NC6H4] and various alcs. Then, quinazoline-amide derivatives I [R1 = H2N, n-PrNH, i-PrNH, PhNH, 4-H2NSO2C6H4NH; R2 = 3-O2NC6H4] were synthesized from the reaction of various amines and compound I [R1 = Cl; R2 = 3-O2NC6H4], obtained by the reaction of compound I [R1 = HO; R2 = 3-O2NC6H4] with SOCl2. Finally, some novel quinazoline-azo derivatives II [R3 = Me, Ph; R4 = Me, EtO] were synthesized by the coupling reaction between β-dicarbonyl compounds and the novel amino-quinazoline derivative compound I [R1 = n-PrNH; R2 = 3-H2NC6H4], obtained by reduction of nitro-quinazoline derivative compound I [R1 = n-PrNH; R2 = 3-O2NC6H4]. Thus, a new series of quinazoline-4-carboxylic acid, ester, amide and azo derivatives was synthesized and fully characterized by 1H NMR, 13C NMR, IR and mass spectrometry anal.
Journal of Heterocyclic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics