Lee, Sangku; Lim, Hee-Jong; Cha, Kobpurn Lulu; Sulikowski, Gary A. published the artcile< Asymmetric approaches to 1,2-disubstituted mitosenes based on the intramolecular cyclization of diazoesters>, Related Products of 30095-98-8, the main research area is mitosene antitumor antibiotic asym synthesis; intramol cyclization diazoester chiral copper catalyst; mitomycin ring system asym synthesis.
A strategy for the asym. synthesis of 1,2-disubstituted mitosenes is described. The key reaction is the decomposition of a meso diazoester in the presence of chiral copper(I) catalysts. Cyclization of diazoesters derived from (1R,2S,5R)-menthol and (R)-pantolactone provide optically pure 1,2-disubstituted mitosenes, e.g. I (R = α-, β-CO2Me; R1 = α-, β-H) following oxidation and purification by flash chromatog.
Tetrahedron published new progress about Antitumor antibiotics. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.
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