Paterson, Ian; Anderson, Edward A.; Dalby, Stephen M.; Lim, Jong Ho; Genovino, Julien; Maltas, Philip; Moessner, Christian published the artcile< Total synthesis of spirastrellolide A methyl ester-part 1: synthesis of an advanced C17-C40 bis-spiroacetal subunit>, Synthetic Route of 617-55-0, the main research area is asym synthesis spirastrellolide A methyl ester fragment Suzuki coupling; bis spiroacetal fragment asym synthesis Suzuki coupling.
The marine macrolide spirastrellolide A is a potent and selective inhibitor of protein phosphatase 2A and a lead for anticancer therapies. A flexible and modular synthetic strategy has been developed with two routes for the construction of the DEF bis-spiroacetal subunit I and II. The optimized Suzuki coupling approach results in the efficient preparation of a C17-C40 aldehyde that forms the cornerstone II of the first total synthesis.
Angewandte Chemie, International Edition published new progress about Olefination (Julia olefination). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics