Kitamura, M.; Tokunaga, M.; Noyori, R. published an article on January 13 ,1993. The article was titled 《Quantitative expression of dynamic kinetic resolution of chirally labile enantiomers: stereoselective hydrogenation of 2-substituted 3-oxo carboxylic esters catalyzed by BINAP-ruthenium(II) complexes》, and you may find the article in Journal of the American Chemical Society.Product Details of 936-03-8 The information in the text is summarized as follows:
Hydrogenation of chirally unstable 2-substituted 3-oxo carboxylic esters gives a mixture of four stereoisomeric hydroxy esters. Use of BINAP-Ru(II) complex catalysts allows selective production of one stereoisomer among four possible isomers. The stereoselectivity obtained by the dynamic kinetic resolution depends on facile in situ racemization of the substrates, efficient chirality recognition ability of the catalysts, and the structures of the ketonic substrates. The factors controlling the efficiency of the stereoselective hydrogenation are exptl. determined by reaction of racemic oxo esters using enantiomerically pure and racemic BINAP complexes. Quant. expression of the dynamic kinetic resolution has been made by defining the product partition coefficients (w, x, y, and z), the relative reactivities of the enantiomeric substrates (kfast/kslow), and the relative ease with which stereoinversion and hydrogenation take place (kinv/kfast). The validity of the equations has been demonstrated by the graphical exhibition of the enantioselectivity and diastereoselectivity as a function of conversion of the substrates. The experimental part of the paper was very detailed, including the reaction process of Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8Product Details of 936-03-8)
Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 936-03-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics