In 2019,European Journal of Organic Chemistry included an article by Yoshimura, Akira; Jarvi, Melissa E.; Shea, Michael T.; Makitalo, Cody L.; Rohde, Gregory T.; Yusubov, Mekhman S.; Saito, Akio; Zhdankin, Viktor V.. SDS of cas: 924-99-2. The article was titled 《Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones》. The information in the text is summarized as follows:
An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from resp. aldoximes using hypervalent iodine reagent was developed for the synthesis of 3,4-disubstituted isoxazoles I [R = n-Pr, Ph, 1-naphthyl, etc.; R1 = H, Me, Ph, etc.; R2 = H, Me]. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of products I in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallog. In the experiment, the researchers used Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2SDS of cas: 924-99-2)
Ethyl 3-(dimethylamino)acrylate(cas: 924-99-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 924-99-2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics