In 2012,Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang published 《Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants》.Journal of Medicinal Chemistry published the findings.Related Products of 16982-21-1 The information in the text is summarized as follows:
Urea-based inhibitors were prepared and characterized in replicase HCV protease-resistant mutants assay. Several compounds, exemplified by I, were found to be more potent in HCV replicon assays than leading second generation inhibitors such as danoprevir and TMC-435350. Addnl., following oral administration, inhibitor I was found in rat liver in significantly higher concentrations than those reported for both danoprevir and TMC-435350, suggesting that inhibitor I has the combination of anti-HCV and pharmacokinetic properties that warrants further development of this series. In addition to this study using Ethyl 2-amino-2-thioxoacetate, there are many other studies that have used Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Related Products of 16982-21-1) was used in this study.
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 16982-21-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics