《Fluorescent Probes for Ecto-5′-nucleotidase (CD73)》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Schmies, Constanze C.; Rolshoven, Georg; Idris, Riham M.; Losenkova, Karolina; Renn, Christian; Schaekel, Laura; Al-Hroub, Haneen; Wang, Yulu; Garofano, Francesca; Schmidt-Wolf, Ingo G. H.; Zimmermann, Herbert; Yegutkin, Gennady G.; Mueller, Christa E.. Safety of N-Boc-1,6-Diaminohexane The article mentions the following:
Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment. In the present study we designed and synthesized fluorescent-labeled CD73 inhibitors with low nanomolar affinity and high selectivity based on N6-benzyl-α,β-methylene-ADP (PSB-12379) as a lead structure. Fluorescein was attached to the benzyl residue via different linkers resulting in PSB-19416 (14b, Ki 12.6 nM) and PSB-18332 (14a, Ki 2.98 nM) as fluorescent high-affinity probes for CD73. These compounds are anticipated to become useful tools for biol. studies, drug screening, and diagnostic applications. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics