Baek, Du-Jong; Kang, Tae-Beom; Kim, Hyun Ju published their research in Bulletin of the Korean Chemical Society on December 20 ,2004. The article was titled 《Synthesis of nonclassical quinazolinone antifolates as thymidylate synthase inhibitors and their antitumor activity in vitro》.Formula: C10H14ClNO2 The article contains the following contents:
Nonclassical quinazolinone analogs, e.g., I (R = H, Me; R1 = H, OH, CO2H, CO2Me), in which the glutamic acid moiety of the classical antifolates is substituted by phenylglycine, phenylalanine or aminobenzoic acid and their Me esters, were synthesized and evaluated as lipophilic inhibitors of thymidylate synthase (TS). The target compounds were generally potent inhibitors of L. casei and human TS with IC50 values within the narrow range of 0.2-10 μM and 0.003-0.03 μM, resp. Further, most of the target compounds showed cytotoxicity against tumor cell lines of murine and human origin with IC50 values of as low as 0.050 μM. Substitution of another hydroxyl or carboxylic acid/ester group at the Ph ring further increased the potency of TS inhibition and cell growth inhibition. Most effective were compounds I (R = H, R1 = CO2H; R = Me, R1 = CO2Me) in which extra carboxylic acid/ester was present at the Ph ring with nanomolar IC50 values of 0.0044 and 0.0093 μM against human TS and submicro-molar cytotoxic growth inhibition against all four tumor cell lines. In addition to this study using H-Phg-OEt.HCl, there are many other studies that have used H-Phg-OEt.HCl(cas: 59410-82-1Formula: C10H14ClNO2) was used in this study.
H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Formula: C10H14ClNO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics