In 2019,Iranian Journal of Pharmaceutical Research included an article by Dahiya, Rajiv; Singh, Sunil; Gupta, Sheeba Varghese; Sutariya, Vijaykumar B.; Bhatia, Deepak; Mourya, Rita; Chennupati, Suresh V.; Sharma, Ajay. HPLC of Formula: 7524-52-9. The article was titled 《First total synthesis and pharmacological potential of a plant based hexacyclopeptide》. The information in the text is summarized as follows:
A new bioactive proline-rich cyclohexapeptide – diandrine C (6), previously isolated from whole plant of Drymaria diandra (Caryophyllaceae), was synthesized through coupling reactions of tetrapeptide unit Boc-Gly-L-Pro-L-Tyr-L-Trp-OH with dipeptide unit L-ProGly-OMe using N,N-diisopropylcarbodiimide (DIPC) as the coupling agent, followed by cyclization of linear hexapeptide unit under alk. condition. Structure of cyclohexapeptide was confirmed by means of chem., and spectroscopic analyses and also was screened for its antimicrobial and anthelmintic properties. Bioevaluation results indicated that the newly synthesized hexacyclopeptide exhibited potent antimicrobial activity against Gram-neg. bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and pathogenic Candida albicans at 6 μg/mL. Moderate to good level of antihelmintic activity against three earthworm species Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniae was also observed at concentration of 2 mg/mL. The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9HPLC of Formula: 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.HPLC of Formula: 7524-52-9
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Ester – Wikipedia,
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