The author of 《Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer》 were Huang, Meng-Ruo; Hsu, Yuan-Ling; Lin, Tzu-Chen; Cheng, Ting-Jen; Li, Ling-Wei; Tseng, Yu-Wei; Chou, Yu-shu; Liu, Jyung-Hurng; Pan, Szu-Hua; Fang, Jim-Min; Wong, Chi-Huey. And the article was published in European Journal of Medicinal Chemistry in 2019. Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate The author mentioned the following in the article:
An 8-oxopurine-6-carboxamide compound, 2-(4-ethoxyphenyl)-9-(2-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxamide [869069-21-6], (1a) was previously identified as an inhibitor of non-small cell lung cancer (NSCLC). In this study, more than 30 purine-6-carboxamide derivatives with variations at the C2, N7, C8, and N9 positions were synthesized to investigate the structure-activity relationship as a basis for the construction of an advanced pharmacophore model. This model suggests that purine-6-hydroxamate and purine-6-amidoxime analogs could form more hydrogen bonds with a target protein to enhance the inhibitory activities against H1975 cells. Among the series of analogs, the hydroxamate, 2-(4-ethoxyphenyl)-9-(2-methoxyphenyl)-8-oxopurine-6(N-hydroxy)carboxamide [2124217-41-8] (17) and amidoxime, (Z)-2-(4-ethoxyphenyl)-N0-hydroxy-9-(2-methoxyphenyl)8-oxo-8,9-dihydro-7H-purine-6-carboximidamide (19a), exhibited excellent potency against H1975 cells (IC50 < 1.5 μM) and other lung cancer cells with either wild-type or mutated epidermal growth factor receptor (EGFR). Mouse experiments indicated that (17) and (19a) were efficient anticancer agents with no appreciable toxicity. The mechanisms of action for the induction of cell apoptosis were determined to involve microtubule fragmentation and p53-mediated signaling pathways. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate
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