《Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents》 was written by Zheng, Xian-Jing; Li, Chun-Shi; Cui, Ming-Yue; Song, Ze-Wen; Bai, Xue-Qian; Liang, Cheng-Wu; Wang, Hui-Yan; Zhang, Tian-Yi. Name: Methyl 4-fluorobenzoate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:
Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their antioxidant and antiinflammatory activities. Among these compounds, 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole and 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)-2-methoxyphenoxy)methyl)-5-(2-chlorophenyl)-1,3,4-oxadiazole were appeared to have high radical scavenging efficacies as 0.05 ± 0.02 and 0.07 ± 0.03 mmol/L of IC50 values in ABTS+· bioassay, resp. In antiinflammatory tests, compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole displayed good activity with 57.35% inhibition after i.p. administration, which was more potent than the reference drug (indomethacin). Mol. modeling studies were performed to study the binding mode of the representative compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole into COX-2 enzyme. In vitro enzyme study implied that compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole exerted its antiinflammatory activity through COX-2 inhibition. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate) was used in this study.
Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate
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