Related Products of 4248-19-5In 2019 ,《Identification of protonated primary carbamates by using gas-phase ion-molecule reactions followed by collision-activated dissociation in tandem mass spectrometry experiments》 appeared in Organic Process Research & Development. The author of the article were Niyonsaba, Edouard; Easton, Mckay W.; Liu, Judy K. Y.; Yu, Zaikuan; Sheng, Huaming; Kong, John Y.; Zhang, Zhoupeng; Easterling, Leah F.; Milton, Jacob; Kenttamaa, Hilkka I.. The article conveys some information:
The levels of potentially mutagenic impurities (PMIs) in active pharmaceutical ingredients are highly regulated and must be below a critical safety threshold. One class of PMIs is primary carbamates, which are formed during drug manufacturing and formulation. To comply with safety regulations, it is critically important to develop anal. techniques that enable the identification of primary carbamates during the drug development process. In this study, tandem mass spectrometry combined with gas-phase ion-mol. reactions as well as collision-activated dissociation (CAD) is demonstrated to enable the identification of protonated primary carbamates. Primary carbamates were protonated via atm. pressure chem. ionization (APCI) in a linear quadrupole ion trap mass spectrometer, isolated, and allowed to react with trimethoxymethylsilane (TMMS) introduced into the ion trap via an external reagent mixing manifold. Protonated primary carbamates reacted with TMMS to form an adduct ion, [M + H + TMMS]+, and an adduct ion that had lost methanol, [M + H + TMMS – MeOH]+. Upon CAD, the [M + H + TMMS – MeOH]+ product ions generated a diagnostic fragment ion via loss of isocyanic acid. Quantum chem. calculations were employed to explore the possible mechanisms for the formation of the product ions upon ion-mol. reactions and for the fragmentation of the [M + H + TMMS – MeOH]+ product ion. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 4248-19-5
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