In 2007,Shearer, Barry G.; Chao, Esther Y.; Uehling, David E.; Deaton, David N.; Cowan, Conrad; Sherman, Bryan W.; Milliken, Tula; Faison, Walter; Brown, Kathleen; Adkison, Kimberly K.; Lee, Frank published 《Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: Ethyl 2-amino-2-thioxoacetate The information in the text is summarized as follows:
Nonracemic (chlorophenethylaminoethylamino)phenyl heteroarylcarboxylic acids such as I are prepared as selective human β3 adrenergic receptor agonists for potential use as agents for the treatment of type 2 diabetes; the selectivities of the heteroarylcarboxylic acids for β3 adrenergic receptors over β1 and β2 adrenergic receptors is determined Aminophenylfurancarboxylate II is prepared by diazotization of 3-nitroaniline and copper-mediated coupling with 3-furancarboxylic acid followed by esterification with methanol and reduction of the nitro group; aldehyde III (TBS = tert-butyldimethylsilyl; Boc = tert-butoxycarbonyl) is prepared by reduction of the corresponding carboxylic acid Me ester. Reductive amination of III with II followed by cleavage of the silyl and butoxycarbonyl groups and base hydrolysis of the ester provides I. The glucose-lowering effect of I upon oral administration to male db/db mice is determined In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Recommanded Product: Ethyl 2-amino-2-thioxoacetate)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: Ethyl 2-amino-2-thioxoacetate
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Ester – Wikipedia,
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