Fang, Jie; Hu, Qiang; Dong, Wan-Li; Xu, Guo-Qiang; Hu, Xiu-Qin; Luo, Yong-Chun; Xu, Peng-Fei published the artcile< Photoredox-catalyzed hydrocarboxymethylation of alkenes>, Electric Literature of 151259-38-0, the main research area is alkene photoredox catalyzed hydrocarboxymethylation.
Direct introduction of a carboxyl group into mols. is one of the most useful methods for the preparation of carboxylic acids, which avoids the conversion of various preexisting functional groups and features good step- and atom-economy. However, the methods for the direct synthesis of two-carbon added carboxylic acids from the precursors remain rare. Herein, we first report a general and mild method for the direct synthesis of a range of aliphatic acids by photoredox-catalyzed hydrocarboxymethylation of alkenes with good toleration of various functional groups in which bromoacetic acid is utilized as an ideal two-carbon synthon. The synthetic utility of this hydrocarboxymethylation protocol is further demonstrated by the concise synthesis of two marketed drugs, sensipar and tirofiban, from com. available starting materials.
CCS Chemistry published new progress about Alkenes Role: TEM (Technical or Engineered Material Use), USES (Uses). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Electric Literature of 151259-38-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics